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COntact US

Integrated Granulation Line (IGL+)

Integrated Granulation Line

What Is Integrated Granulation Line?

An Integrated Granulation Line (IGL) is a fully contained, multi-stage pharmaceutical processing system that combines all key steps of the wet granulation process, sifting, mixing, granulating, fluid bed drying, and milling, into a single, unified production station. Rather than operating each process step as a separate, standalone unit with manual material transfer between them, an integrated granulation line connects and sequences each stage within one contained environment, eliminating open handling, reducing contamination risk, and significantly improving process efficiency.

The F Plus IGL+ takes this concept further. Designed for pharmaceutical manufacturers working with complex formulations, potent compounds, or high-value products, the IGL+ delivers simultaneous multi-stage processing, isolator compatibility, and a compact footprint, making it equally suited for feasibility-scale development batches and contained commercial production. With GAMP5, CE, ATEX, and cGMP certification, and built-in data integrity features for regulatory traceability, the IGL+ represents a complete, future-ready granulation solution engineered for the demands of modern pharmaceutical manufacturing.

Why Choose the F Plus IGL+ ?

A fully contained, simultaneous granulation system engineered for high-containment, high-efficiency pharmaceutical production, from feasibility batches to commercial scale.

Strategy and Planning

Multi-staged operation at a single station enables simultaneous processing across granulation stages, reducing overall batch cycle time, improving throughput, and eliminating the idle time associated with sequential standalone unit operations.

Small Footprint

The IGL+ is designed with a compact footprint that maximises production capacity within a minimal floor area. Its fully contained architecture is ideal for space-constrained pharmaceutical manufacturing environments without compromising process capability or output quality.

Isolator Compatible

Specifically engineered for integration with isolator systems, the IGL+ supports high-containment processing of potent active pharmaceutical ingredients, cytotoxic compounds, and highly sensitising materials, meeting the most stringent operator and environmental protection requirements.

Feasibility Batches

Scaled-down batch size capability makes the IGL+ ideally suited for early-stage feasibility studies, formulation development trials, and process optimisation runs, particularly for expensive, rare, or limited-availability active ingredients where material conservation is critical.

Toolless Changeover

Designed for single-operator, tool-less changeover of all process units, the IGL+ minimises cleaning time, reduces the risk of changeover errors, and accelerates product switchover, improving line utilisation in multi-product manufacturing environments.

Plug-and-Play

The IGL+ is built as a simple, plug-and-play system, requiring minimal installation complexity. Its modular architecture enables rapid startup, straightforward integration into existing facility layouts, and future scalability as production requirements evolve.

Lower Cross-Contamination Risk

The fully contained design of the IGL+ eliminates open material transfers between process stages, significantly reducing the risk of cross-contamination between products and batches, a critical requirement for multi-product pharmaceutical facilities.

Data Integrity

Built-in data integrity features ensure complete, tamper-evident record-keeping for every batch, supporting regulatory-compliant traceability, audit trail generation, and documentation requirements across international markets.

Global Compliance

The F Plus IGL+ is certified to GAMP5, CE, ATEX, and cGMP standards, enabling regulatory acceptance across major global pharmaceutical markets including the US, EU, and India.

Ready to consolidate your granulation process?

The IGL+ is built for manufacturers who need high-containment, high-efficiency granulation in a compact, compliant, and future-ready system.
Share your formulation type, batch size, containment requirements, and production scale with our team and let’s configure the right IGL+ solution for your facility.

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Frequently Asked Questions

Questions before you begin?

Start with the essentials, then speak with our team about your formulation, capacity and facility requirements.

An Integrated Granulation Line combines sifting, high shear mixing and wet granulation, fluid bed drying, milling, and contained transfer within a coordinated processing system.

IGL Plus connects major process stages and supports contained transfers, reducing open handling, intermediate movement, product loss, and exposure risk between granulation operations.

Yes. The line is designed to support small feasibility or development batches as well as scale-up and commercial production, subject to the selected configuration and batch range.

It can be configured with containment and isolator compatibility for potent or sensitising materials. The required containment strategy should be based on a formal product and exposure-risk assessment.

Tool-less changeover can reduce dismantling time, simplify operator tasks, and shorten the transition between batches or products while supporting repeatable reassembly.

 

Available configurations can support process monitoring, recipe control, electronic records, audit trails, data integrity, and cGMP-focused documentation according to project requirements.

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